产品名称
ZN521 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25925
Human Swissprot No.
Q96K83
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96K83/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/225207
Mouse Swissprot No.
Q6KAS7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6KAS7
免疫原
Synthesized peptide derived from human ZN521 AA range: 997-1047
特异性
This antibody detects endogenous levels of ZN521 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.
功能
disease:A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.,domain:Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system.,function:Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 30 C2H2-type zinc fingers.,subunit:Interacts with EBF1. Interacts with SMAD1 and SMAD4.,tissue specificity:Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
