产品名称
TXD12 Rabbit Polyclonal Antibody
基因名称
TXNDC12 TLP19 UNQ713/PRO1376
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51060
Human Swissprot No.
O95881
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95881/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66073
Mouse Swissprot No.
Q9CQU0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQU0
Rat Gene Link
https://www.uniprot.org/uniprot/298370
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q498E0
免疫原
Synthesized peptide derived from human TXD12 AA range: 118-168
特异性
This antibody detects endogenous levels of TXD12 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012],
细胞定位
Endoplasmic reticulum lumen .
功能
catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,function:Possesses significant protein thiol-disulfide oxidase activity.,function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
