产品名称
UN13B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10497
Human Swissprot No.
O14795
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14795/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22249
Mouse Swissprot No.
Q9Z1N9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1N9
Rat Gene Link
https://www.uniprot.org/uniprot/64830
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62769
免疫原
Synthesized peptide derived from human UN13B AA range: 1325-1375
特异性
This antibody detects endogenous levels of UN13B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008],
组织表达
Expressed in kidney cortical epithelial cells and brain.
细胞定位
Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
功能
domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.,subunit:Interacts with RIMS1.,tissue specificity:Expressed in kidney cortical epithelial cells and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
