产品名称
SRGP1 Rabbit Polyclonal Antibody
基因名称
SRGAP1 ARHGAP13 KIAA1304
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57522
Human Swissprot No.
Q7Z6B7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z6B7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/117600
Mouse Swissprot No.
Q91Z69
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z69
免疫原
Synthesized peptide derived from human SRGP1 AA range: 159-209
特异性
This antibody detects endogenous levels of SRGP1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016],
组织表达
Expressed in brain, lung, kidney, and testis.
功能
function:GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.,sequence caution:Intron retention.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ROBO1, CDC42 and RHOA.,tissue specificity:Expressed in brain, lung, kidney, and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
