产品名称
TRAD1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10906
Human Swissprot No.
O14545
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14545/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/231712
Mouse Swissprot No.
Q3UDK1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UDK1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99MM4
免疫原
Synthesized peptide derived from human TRAD1 AA range: 52-102
特异性
This antibody detects endogenous levels of TRAD1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009],
功能
function:May function as a lipopolysaccharide (LPS)-inducible negative regulator in innate immunity. May be involved in endotoxin tolerance. Seems to act as a negative regulator in toll-like receptor signaling.,induction:LPS, IFNB1 and IFNG increased protein levels in RAW cells with IFNB1 being most potent inducer. IL4 and IL10 did not induced the expression in RAW cells, moreover, LPS did not induce expression in the presence of IL4 or IL10.,similarity:Contains 1 TRAF-type zinc finger.,subunit:Interacts with TRAF6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
