产品名称
AGK Rabbit Polyclonal Antibody
蛋白名称
Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q53H12
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q53H12/entry
Mouse Swissprot No.
Q9ESW4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ESW4
免疫原
Synthesized peptide derived from human protein . at AA range: 330-410
特异性
AGK Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012],
组织表达
Highly expressed in muscle, heart, kidney and brain.
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726). .
信号通路
Glycerolipid metabolism;
功能
catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,catalytic activity:ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.,cofactor:Magnesium.,function:Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.,miscellaneous:Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles.,pathway:Lipid metabolism; glycerolipid metabolism.,similarity:Contains 1 DAGKc domain.,tissue specificity:Highly expressed in muscle, heart, kidney and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
