产品名称
I5P2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3633
Human Swissprot No.
P32019
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P32019/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16330
Mouse Swissprot No.
Q8K337
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K337
免疫原
Synthesized peptide derived from human I5P2 AA range: 292-342
特异性
This antibody detects endogenous levels of I5P2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014],
细胞定位
Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment . Early endosome membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane . Golgi apparatus .
功能
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Hydrolyzes the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
