产品名称
CNOT6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57472
Human Swissprot No.
Q9ULM6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULM6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/104625
Mouse Swissprot No.
Q8K3P5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3P5
Rat Gene Link
https://www.uniprot.org/uniprot/287249
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AXU9
免疫原
Synthesized peptide derived from human CNOT6 AA range: 293-343
特异性
This antibody detects endogenous levels of CNOT6 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014],
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic. .
功能
cofactor:Magnesium.,function:Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex.,similarity:Belongs to the CCR4/nocturin family.,similarity:Contains 3 LRR (leucine-rich) repeats.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
