产品名称
SAC2 Rabbit Polyclonal Antibody
基因名称
INPP5F KIAA0966 SAC2 MSTP007 MSTP047
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/22876
Human Swissprot No.
Q9Y2H2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2H2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/101490
Mouse Swissprot No.
Q8CDA1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CDA1
免疫原
Synthesized peptide derived from human SAC2 AA range: 1006-1056
特异性
This antibody detects endogenous levels of SAC2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
组织表达
Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
细胞定位
Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .
功能
function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
