产品名称
RIP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84268
Human Swissprot No.
Q86UA6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86UA6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/69723
Mouse Swissprot No.
Q9CWY9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CWY9
Rat Gene Link
https://www.uniprot.org/uniprot/287463
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4G2Y1
免疫原
Synthesized peptide derived from human RIP AA range: 117-167
特异性
This antibody detects endogenous levels of RIP at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
组织表达
Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
细胞定位
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.
功能
function:Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.,PTM:Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.,similarity:Contains 1 RIP-type zinc finger.,subcellular location:Only nuclear, localizes to PML body.,subunit:Interacts with the RPA1 subunit of RPA complex.,tissue specificity:Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
