产品名称
DEN1A Rabbit Polyclonal Antibody
基因名称
DENND1A FAM31A KIAA1608
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57706
Human Swissprot No.
Q8TEH3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TEH3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/227801
Mouse Swissprot No.
Q8K382
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K382
免疫原
Synthesized peptide derived from human DEN1A AA range: 14-64
特异性
This antibody detects endogenous levels of DEN1A at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],
细胞定位
Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .
功能
function:May be involved in the clathrin-mediated endocytosis of synaptic vesicles.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,subunit:Interacts with AP2B1, ITSN1 AND SH3GL2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
