产品名称
SG196 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84197
Human Swissprot No.
Q9H5K3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H5K3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74653
Mouse Swissprot No.
Q3TUA9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TUA9
Rat Gene Link
https://www.uniprot.org/uniprot/306549
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V8A9
免疫原
Synthesized peptide derived from human SG196 AA range: 178-228
特异性
This antibody detects endogenous levels of SG196 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
组织表达
Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
功能
domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
