产品名称
ZFY27 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/118813
Human Swissprot No.
Q5T4F4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5T4F4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/319740
Mouse Swissprot No.
Q3TXX3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TXX3
Rat Gene Link
https://www.uniprot.org/uniprot/309376
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P7B7
免疫原
Synthesized peptide derived from human ZFY27 AA range: 351-401
特异性
This antibody detects endogenous levels of ZFY27 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010],
细胞定位
Recycling endosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, growth cone membrane ; Multi-pass membrane protein . Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network. .
功能
disease:Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33) [MIM:610244]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,similarity:Contains 1 FYVE-type zinc finger.,subcellular location:Punctate vesicles.,subunit:Interacts with SPAST/spastin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
