产品名称
NH2L1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4809
Human Swissprot No.
P55769
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55769/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/100862468
Mouse Swissprot No.
Q9D0T1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D0T1
Rat Gene Link
https://www.uniprot.org/uniprot/100359574
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P55770
免疫原
Synthesized peptide derived from human NH2L1 AA range: 33-83
特异性
This antibody detects endogenous levels of NH2L1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus. .
功能
function:Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.,similarity:Belongs to the ribosomal protein L7Ae family.,subcellular location:Concentrated in the dense fibrillar component of the nucleolus.,subunit:Interacts with RAD17.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
