产品名称
AT134 Rabbit Polyclonal Antibody
基因名称
ATP13A4 UNQ3052/PRO9871
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84239
Human Swissprot No.
Q4VNC1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q4VNC1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/224079
Mouse Swissprot No.
Q5XF90
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XF90
免疫原
Synthesized peptide derived from human AT134 AA range: 719-769
特异性
This antibody detects endogenous levels of AT134 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen (PubMed:15925480). Highly expressed in the respiratory and integumentary systems (PubMed:29505581).
细胞定位
Early endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
功能
catalytic activity:ATP + H(2)O = ADP + phosphate.,disease:A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein.,induction:Decreased by half in the SLI patient lymphoblasts.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type V subfamily.,tissue specificity:Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
