产品名称
LMA2L Rabbit Polyclonal Antibody
基因名称
LMAN2L VIPL PSEC0028 UNQ368/PRO704
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81562
Human Swissprot No.
Q9H0V9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0V9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/214895
Mouse Swissprot No.
P59481
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P59481
免疫原
Synthesized peptide derived from human LMA2L AA range: 56-106
特异性
This antibody detects endogenous levels of LMA2L at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016],
组织表达
Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
功能
function:May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.,similarity:Contains 1 L-type lectin-like domain.,subcellular location:Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.,tissue specificity:Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
