产品名称
TTYH2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/94015
Human Swissprot No.
Q9BSA4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BSA4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/117160
Mouse Swissprot No.
Q3TH73
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TH73
免疫原
Synthesized peptide derived from human TTYH2 AA range: 319-369
特异性
This antibody detects endogenous levels of TTYH2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation.,similarity:Belongs to the tweety family.,tissue specificity:Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
