产品名称
XPO4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64328
Human Swissprot No.
Q9C0E2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9C0E2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57258
Mouse Swissprot No.
Q9ESJ0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESJ0
免疫原
Synthesized peptide derived from human XPO4 AA range: 244-294
特异性
This antibody detects endogenous levels of XPO4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009],
细胞定位
Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. .
功能
function:Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,similarity:Belongs to the exportin family.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
