产品名称
TDH Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q8IZJ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZJ6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/58865
Mouse Swissprot No.
Q8K3F7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3F7
免疫原
Synthesized peptide derived from human TDH AA range: 169-219
特异性
This antibody detects endogenous levels of TDH at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.
功能
caution:According to PubMed:12361482, the human TDH gene is an expressed pseudogene encoding non-functional truncated proteins that are unable to make appropriate contacts with the substrates, L-threonine and NAD(+). Although all exons expected to encode a functional L-threonine 3-dehydrogenase of 369 residues are present in the human genome, all transcripts described encode truncated proteins that result from mutations within the gene causing the loss of acceptor splice site preceding exon 4 and exon 6.,similarity:Belongs to the sugar epimerase family.,tissue specificity:Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
