产品名称
UBP25 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29761
Human Swissprot No.
Q9UHP3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHP3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/30940
Mouse Swissprot No.
P57080
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P57080
免疫原
Synthesized peptide derived from human UBP25 AA range: 883-933
特异性
This antibody detects endogenous levels of UBP25 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008],
组织表达
Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific.
细胞定位
Cytoplasm .; [Isoform USP25m]: Cytoplasm . Nucleus . Some transient punctuate nuclear location in myotubes during myocyte development. .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,tissue specificity:Found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
