产品名称
S20A2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6575
Human Swissprot No.
Q08357
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q08357/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20516
Mouse Swissprot No.
Q80UP8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80UP8
Rat Gene Link
https://www.uniprot.org/uniprot/29502
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63488
免疫原
Synthesized peptide derived from human S20A2 AA range: 370-420
特异性
This antibody detects endogenous levels of S20A2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
组织表达
Ubiquitously expressed.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.,induction:Increased by phosphate depletion in osteosarcoma cell lines.,similarity:Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.,subunit:Homodimer.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
