产品名称
PMM1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5372
Human Swissprot No.
Q92871
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92871/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29858
Mouse Swissprot No.
O35621
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35621
免疫原
Synthesized peptide derived from human PMM1 AA range: 18-68
特异性
This antibody detects endogenous levels of PMM1 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008],
组织表达
Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
功能
catalytic activity:Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.,function:Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.,pathway:Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.,similarity:Belongs to the eukaryotic PMM family.,tissue specificity:Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.