产品名称
TYDP2 Rabbit Polyclonal Antibody
基因名称
TDP2 EAP2 TTRAP AD-022
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51567
Human Swissprot No.
O95551
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95551/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56196
Mouse Swissprot No.
Q9JJX7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJX7
Rat Gene Link
https://www.uniprot.org/uniprot/498749
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3T1H5
免疫原
Synthesized peptide derived from human TYDP2 AA range: 261-311
特异性
This antibody detects endogenous levels of TYDP2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003).
细胞定位
Nucleus . Nucleus, PML body . Nucleus, nucleolus . Cytoplasm. Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. .; Cytoplasm . (Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
