产品名称
EXOS1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51013
Human Swissprot No.
Q9Y3B2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y3B2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66583
Mouse Swissprot No.
Q9DAA6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DAA6
免疫原
Synthesized peptide derived from human EXOS1 AA range: 93-143
特异性
This antibody detects endogenous levels of EXOS1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016],
细胞定位
Nucleus, nucleolus . Nucleus . Cytoplasm .
功能
domain:The N- and C-terminal regions of the protein are required for interaction with RRP46.,function:Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.,similarity:Contains 1 S1 motif domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Interacts directly with EXOSC5, EXOSC6, EXOSC7 and EXOSC8. Also associated with the GTPase Ran.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
