BD-PT7028

CHMP6 Rabbit Polyclonal Antibody

常规抗体

CHMP6 VPS20

CHMP6

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

79643

https://www.uniprot.org/uniprot/79643

Q96FZ7

https://www.uniprot.org/uniprotkb/Q96FZ7/entry

208092

https://www.uniprot.org/uniprot/208092

P0C0A3

https://www.uniprot.org/uniprotkb/P0C0A3

Synthesized peptide derived from human CHMP6 AA range: 87-137

This antibody detects endogenous levels of CHMP6 at Human/Mouse

WB 1：500-2000

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012],

Ubiquitously expressed.

Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane . Membrane ; Lipid-anchor . Localizes to endosomal membranes.

domain:The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.,function:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.,similarity:Belongs to the SNF7 family.,subcellular location:Localizes to endosomal membranes.,subunit:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36.,tissue specificity:Ubiquitously expressed.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.