产品名称
KIF5A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3798
Human Swissprot No.
Q12840
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12840/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16572
Mouse Swissprot No.
P33175
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P33175
Rat Gene Link
https://www.uniprot.org/uniprot/314906
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6QLM7
免疫原
Synthesized peptide derived from human KIF5A AA range: 213-263
特异性
This antibody detects endogenous levels of KIF5A at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008],
组织表达
Distributed throughout the CNS but is highly enriched in subsets of neurons.
细胞定位
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Perikaryon . Concentrated in the cell body of the neurons, particularly in the perinuclear region. .
功能
disease:Defects in KIF5A are the cause of spastic paraplegia type 10 (SPG10) [MIM:604187]. SPG10 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Concentrated in the cell body of the neurons, particularly in the perinuclear region.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.,tissue specificity:Distributed throughout the CNS but is highly enriched in subsets of neurons.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
