产品名称
ZNT6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55676
Human Swissprot No.
Q6NXT4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NXT4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/210148
Mouse Swissprot No.
Q8BJM5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BJM5
免疫原
Synthesized peptide derived from human ZNT6 AA range: 58-108
特异性
This antibody detects endogenous levels of ZNT6 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016],
组织表达
Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.
细胞定位
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Found in vesicles. .
功能
function:Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.,miscellaneous:Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with znt5.,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,subcellular location:Found in vesicules.,subunit:Heterooligomer. Interacts with ZNT5.,tissue specificity:Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
