产品名称
SDS3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64426
Human Swissprot No.
Q9H7L9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H7L9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71954
Mouse Swissprot No.
Q8BR65
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BR65
免疫原
Synthesized peptide derived from human SDS3 AA range: 96-146
特异性
This antibody detects endogenous levels of SDS3 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in various cancer cell ines.
功能
domain:The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Belongs to the SDS3 family.,subunit:Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.,tissue specificity:Expressed in various cancer cell ines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
