产品名称
TFB2M Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64216
Human Swissprot No.
Q9H5Q4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H5Q4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/15278
Mouse Swissprot No.
Q3TL26
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TL26
Rat Gene Link
https://www.uniprot.org/uniprot/289307
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2T7
免疫原
Synthesized peptide derived from human TFB2M AA range: 192-242
特异性
This antibody detects endogenous levels of TFB2M at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed.
功能
function:S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.,induction:By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators.,similarity:Belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily.,subunit:Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
