产品名称
KDM4C Rabbit Polyclonal Antibody
基因名称
KDM4C GASC1 JHDM3C JMJD2C KIAA0780
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23081
Human Swissprot No.
Q9H3R0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H3R0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/76804
Mouse Swissprot No.
Q8VCD7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCD7
免疫原
Synthesized peptide derived from human KDM4C AA range: 737-787
特异性
This antibody detects endogenous levels of KDM4C at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
功能
cofactor:Binds 1 Fe(2+) ion per subunit.,domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.,function:Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.,similarity:Belongs to the JHDM3 histone demethylase family.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,similarity:Contains 2 Tudor domains.,tissue specificity:Overexpressed in several esophageal squamous cell carcinomas (ESCs).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
