产品名称
PSD10 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5716
Human Swissprot No.
O75832
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75832/entry
Mouse Swissprot No.
Q9Z2X2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2X2
Rat Gene Link
https://www.uniprot.org/uniprot/116722
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2X3
免疫原
Synthesized peptide derived from human PSD10 AA range: 86-136
特异性
This antibody detects endogenous levels of PSD10 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011],
组织表达
Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
细胞定位
Cytoplasm . Nucleus .
功能
function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Contains 7 ANK repeats.,subunit:Component of the PA700 complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
