产品名称
CRGA Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1418
Human Swissprot No.
P11844
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11844/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12964
Mouse Swissprot No.
P04345
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P04345
Rat Gene Link
https://www.uniprot.org/uniprot/684028
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P10065
免疫原
Synthesized peptide derived from human CRGA AA range: 105-155
特异性
This antibody detects endogenous levels of CRGA at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008],
功能
domain:Has a two-domain beta-structure, folded into four very similar Greek key motifs.,function:Crystallins are the dominant structural components of the vertebrate eye lens.,similarity:Belongs to the beta/gamma-crystallin family.,similarity:Contains 4 beta/gamma crystallin 'Greek key' domains.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
