BD-PN0112

DMP1 Rabbit Polyclonal Antibody

常规抗体

DMP1

Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1758

Q13316

https://www.uniprot.org/uniprotkb/Q13316/entry

O55188

http://www.uniprot.org/uniprot/O55188

P98193

http://www.uniprot.org/uniprot/O54941P98193

Synthesized peptide derived from human protein . at AA range: 430-510

DMP1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

56kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conser

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.

Nucleus . Cytoplasm . Secreted, extracellular space, extracellular matrix . In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.

disease:Defects in DMP1 are the cause of autosomal recessive hypophosphatemic rickets (ARHR) [MIM:241520]. ARHR is characterized by rickets, osteomalacia, elevated FGF23 serum levels and hypophosphatemia.,function:May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.,PTM:Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium.,subcellular location:In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.,subunit:Interacts with importin alpha.,tissue specificity:Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.