产品名称
FBXL5 Rabbit Polyclonal Antibody
基因名称
FBXL5 FBL4 FBL5 FLR1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26234
Human Swissprot No.
Q9UKA1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKA1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/242960
Mouse Swissprot No.
Q8C2S5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C2S5
免疫原
Synthesized peptide derived from human FBXL5 AA range: 319-369
特异性
This antibody detects endogenous levels of FBXL5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010],
细胞定位
Cytoplasm, perinuclear region .
功能
function:Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.,similarity:Contains 1 F-box domain.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
