产品名称
SPG16 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79582
Human Swissprot No.
Q8N0X2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N0X2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66722
Mouse Swissprot No.
Q8K450
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K450
免疫原
Synthesized peptide derived from human SPG16 AA range: 520-570
特异性
This antibody detects endogenous levels of SPG16 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008],
组织表达
Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, flagellum axoneme . Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, cilium, flagellum . Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). .
功能
function:Necessary for sperm flagellar function.,similarity:Contains 7 WD repeats.,subcellular location:Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules.,subunit:Interacts with SPAG6.,tissue specificity:Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
