产品名称
NCS1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23413
Human Swissprot No.
P62166
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62166/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14299
Mouse Swissprot No.
Q8BNY6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BNY6
Rat Gene Link
https://www.uniprot.org/uniprot/65153
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62168
免疫原
Synthesized peptide derived from human NCS1 AA range: 3-53
特异性
This antibody detects endogenous levels of NCS1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Golgi apparatus . Cell junction, synapse, postsynaptic density . Cytoplasm, perinuclear region . Cytoplasm . Cell membrane ; Peripheral membrane protein. Membrane ; Lipid-anchor . Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. .
功能
function:Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin.,miscellaneous:Binds 3 calcium ions via the second, third and fourth EF-hand.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,subcellular location:Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.,subunit:Interacts with KCND2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
