产品名称
ZN423 Rabbit Polyclonal Antibody
基因名称
ZNF423 KIAA0760 NPHP14 OAZ
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23090
Human Swissprot No.
Q2M1K9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q2M1K9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/94187
Mouse Swissprot No.
Q80TS5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TS5
Rat Gene Link
https://www.uniprot.org/uniprot/94188
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08961
免疫原
Synthesized peptide derived from human ZN423 AA range: 848-898
特异性
This antibody detects endogenous levels of ZN423 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012],
组织表达
Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum.
功能
domain:Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs.,function:Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 30 C2H2-type zinc fingers.,subunit:Homodimer (By similarity). Interacts with PARP1 and EBF1 (By similarity). Interacts with SMAD1 and SMAD4.,tissue specificity:Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
