产品名称
ZBT17 Rabbit Polyclonal Antibody
基因名称
ZBTB17 MIZ1 ZNF151 ZNF60
蛋白名称
Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13105
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13105/entry
Mouse Swissprot No.
Q60821
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60821
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
ZBT17 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008],
组织表达
Expressed in germinal center B-cells.
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 13 C2H2-type zinc fingers.,subunit:Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
