产品名称
TBCD7 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51256
Human Swissprot No.
Q9P0N9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P0N9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67046
Mouse Swissprot No.
Q9D0K0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D0K0
免疫原
Synthesized peptide derived from human TBCD7 AA range: 85-135
特异性
This antibody detects endogenous levels of TBCD7 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the TBC-domain containing protein family. The encoded protein functions as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in this gene have been associated with autosomal recessive megalencephaly. Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between this locus and downstream LOC100130357. [provided by RefSeq, Jan 2016],
组织表达
Highly expressed in heart, and slightly in kidney, liver and placenta.
细胞定位
Cytoplasmic vesicle . Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
功能
function:May act as a GTPase-activating protein for Rab family protein(s) .,similarity:Contains 1 Rab-GAP TBC domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
