产品名称
SNX17 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9784
Human Swissprot No.
Q15036
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15036/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/266781
Mouse Swissprot No.
Q8BVL3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVL3
Rat Gene Link
https://www.uniprot.org/uniprot/298836
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYS6
免疫原
Synthesized peptide derived from human SNX17 AA range: 398-448
特异性
This antibody detects endogenous levels of SNX17 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012],
细胞定位
Cytoplasm . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
domain:The PX domain is required for association with endosomes.,function:May be involved in protein trafficking.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 1 Ras-associating domain.,subcellular location:Associated with early endosomes.,subunit:Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
