产品名称
BHE22 Rabbit Polyclonal Antibody
基因名称
BHLHE22 BHLHB5 TNRC20
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27319
Human Swissprot No.
Q8NFJ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NFJ8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/59058
Mouse Swissprot No.
Q8C6A8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C6A8
免疫原
Synthesized peptide derived from human BHE22 AA range: 243-293
特异性
This antibody detects endogenous levels of BHE22 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016],
组织表达
Brain-specific, with the highest expression in the cerebellum.
功能
function:Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Brain-specific, with the highest expression in the cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
