产品名称
LX15B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/247
Human Swissprot No.
O15296
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15296/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11688
Mouse Swissprot No.
O35936
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35936
Rat Gene Link
https://www.uniprot.org/uniprot/266604
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K4F2
免疫原
Synthesized peptide derived from human LX15B AA range: 576-626
特异性
This antibody detects endogenous levels of LX15B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
组织表达
Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
细胞定位
[Isoform A]: Nucleus . Other isoforms are excluded from the nucleus. .; Cytoplasm, cytosol . Cell membrane . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, focal adhesion . Predominantly cytosolic; becomes enriched at membranes upon calcium binding. .
功能
catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,tissue specificity:Expressed in hair, prostate, lung and cornea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
