产品名称
NALP4 Rabbit Polyclonal Antibody
基因名称
NLRP4 NALP4 PAN2 PYPAF4 RNH2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/147945
Human Swissprot No.
Q96MN2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96MN2/entry
免疫原
Synthesized peptide derived from human NALP4 AA range: 307-357
特异性
This antibody detects endogenous levels of NALP4 at Human
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008],
细胞定位
cytosol,extracellular exosome,
功能
alternative products:Experimental confirmation may be lacking for some isoforms,function:May be involved in inflammation.,sequence caution:Translated as Gln.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
