产品名称
FXL12 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54850
Human Swissprot No.
Q9NXK8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NXK8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/30843
Mouse Swissprot No.
Q9EPX5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPX5
免疫原
Synthesized peptide derived from human FXL12 AA range: 8-58
特异性
This antibody detects endogenous levels of FXL12 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008],
细胞定位
ubiquitin ligase complex,cytoplasm,integral component of membrane,
功能
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subunit:Interacts with SKP1A and CUL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
