产品名称
TFCP2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7024
Human Swissprot No.
Q12800
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12800/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21422
Mouse Swissprot No.
Q9ERA0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERA0
免疫原
Synthesized peptide derived from human TFCP2 AA range: 21-71
特异性
This antibody detects endogenous levels of TFCP2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010],
组织表达
Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
功能
developmental stage:Expressed in fetal erythroid tissue.,function:Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.,miscellaneous:In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 2 over isoform 1 inhibited DNA-binding.,similarity:Belongs to the grh/CP2 family. CP2 subfamily.,subunit:Binds to DNA as a dimer, isoform 2 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.,tissue specificity:Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
