产品名称
JAZF1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/221895
Human Swissprot No.
Q86VZ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86VZ6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/231986
Mouse Swissprot No.
Q80ZQ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80ZQ5
免疫原
Synthesized peptide derived from human JAZF1 AA range: 57-107
特异性
This antibody detects endogenous levels of JAZF1 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008],
组织表达
Highest expression in testis with moderate levels in colon, placenta, prostate and ovary and low levels in brain, spleen, liver and small intestine.
功能
disease:A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.,function:Potential transcription factor.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with TAK1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
