产品名称
EPS8 Rabbit Polyclonal Antibody
蛋白名称
Epidermal growth factor receptor kinase substrate 8
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q12929
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12929/entry
Mouse Swissprot No.
Q08509
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q08509
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
EPS8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
细胞定位
Cytoplasm, cell cortex . Cell projection, ruffle membrane . Cell projection, growth cone . Cell projection, stereocilium . Cell junction, synapse, synaptosome . Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. .
功能
domain:The SH3 domain mediates interaction with SHB.,function:Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.,PTM:Phosphorylated by several receptor tyrosine kinases.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer (By similarity). Interacts with BAIAP2. Interacts with SHB.,tissue specificity:Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
