产品名称
AP4A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/318
Human Swissprot No.
P50583
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50583/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66401
Mouse Swissprot No.
P56380
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P56380
Rat Gene Link
https://www.uniprot.org/uniprot/297998
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PEC0
免疫原
Synthesized peptide derived from human AP4A AA range: 93-143
特异性
This antibody detects endogenous levels of AP4A at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011],
细胞定位
mitochondrial matrix,
功能
catalytic activity:P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.,cofactor:Divalent ions.,function:Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.,similarity:Belongs to the Nudix hydrolase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
