产品名称
CLLU1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/574028
Human Swissprot No.
Q5K131
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5K131/entry
免疫原
Synthesized peptide derived from human CLLU1 AA range: 23-73
特异性
This antibody detects endogenous levels of CLLU1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is overexpressed in chronic lymphocytic leukemia (CLL) and serves as a good prognostic marker for the disease. Methylation of certain genes, including this one, have been associated with CLL. This gene is protein-coding in humans and non-protein coding in other primates. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patients before and after treatment.
细胞定位
Cytoplasm . Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.
功能
disease:High CLLU1 expression in patients with CLL is associated with poor clinical outcome.,miscellaneous:Tridimensional modeling predicts that it may interact with the IL-4 receptor.,tissue specificity:Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
