产品名称
ZRAN1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54764
Human Swissprot No.
Q9UGI0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UGI0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/360216
Mouse Swissprot No.
Q7M760
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7M760
免疫原
Synthesized peptide derived from human ZRAN1 AA range: 255-305
特异性
This antibody detects endogenous levels of ZRAN1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Cytoplasm . Nucleus . Enriched in punctate localization in the cytoplasm. .
功能
domain:The OTU domain mediates the deubiquitinating activity.,domain:The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin.,function:Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 3 RanBP2-type zinc fingers.,subunit:Interacts with APC and TRAF6.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
